Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer

Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer

Despite the ample improvements of CRC molecular landscape, the therapeutic options still rely on conventional chemotherapy-based regimens for early disease, and few targeted agents are recommended for clinical use in the metastatic setting. Moreover, the impact of cytotoxic, targeted agents, and imm...

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Bibliographic Details
Main Authors: Paula Pellenz Tomasini, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Sarah Péricart, Anne-Cécile Brunac, Jean Sébastien Hoffmann, Jenifer Saffi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
colorectal cancer
DNA double strand break repair
replication stress
target therapy
Online Access:https://www.mdpi.com/2072-6694/13/13/3130

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https://www.mdpi.com/2072-6694/13/13/3130

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