Nonmuscle Myosin Heavy Chain ⅡA-Mediated Exosome Release via Regulation of the Rho-Associated Kinase 1/Myosin Light Chains/Actin Pathway

Nonmuscle Myosin Heavy Chain ⅡA-Mediated Exosome Release via Regulation of the Rho-Associated Kinase 1/Myosin Light Chains/Actin Pathway

Nonmuscle myosin ⅡA, a kind of ATP-dependent molecular motor, binds actin to form the molecular motors of the cell. We found that interfering with nonmuscle myosin heavy chain (NMMHC) ⅡA could affect the exosome release from microglial cells stimulated by LPS. LPS could enhance exosome release from...

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Bibliographic Details
Main Authors: Yanni Lv, Jin Chen, Jinfang Hu, Yisong Qian, Ying Kong, Longsheng Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
nonmuscle myosin heavy chain IIA
exosome release
rho-associated kinase 1/myosin light chains/actin
microglial cells
lipopolysaccharide
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.598592/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.598592/full

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