Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway. Alternatively, nicotinic acid (NA) is metabolized to NA...

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Bibliographic Details
Main Authors: Thomas O'Brien, Jason Oeh, Yang Xiao, Xiaorong Liang, Alexander Vanderbilt, Ann Qin, Lulu Yang, Leslie B. Lee, Justin Ly, Ely Cosino, Jennifer A. LaCap, Annie Ogasawara, Simon Williams, Michelle Nannini, Bianca M. Liederer, Peter Jackson, Peter S. Dragovich, Deepak Sampath
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800012

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http://www.sciencedirect.com/science/article/pii/S1476558613800012

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