Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. Mechanistically, the major cause of the disease bases on the altered processing of the amyloid-β (Aβ) precursor protein (APP), resulting in the accumulation and aggregat...

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Bibliographic Details
Main Authors: Michela Guglielmotto, Luca Giliberto, Elena Tamagno, Massimo Tabaton
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.24.003.2010/full