Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

Gene-environment interactions impact the development of neuropsychiatric disorders, but the relative contributions are unclear. Here, we identify gut microbiota as sufficient to induce depressive-like behaviors in genetically distinct mouse strains. Daily gavage of vehicle (dH2O) in nonobese diabeti...

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Bibliographic Details
Main Authors: Mar Gacias, Sevasti Gaspari, Patricia-Mae G Santos, Sabrina Tamburini, Monica Andrade, Fan Zhang, Nan Shen, Vladimir Tolstikov, Michael A Kiebish, Jeffrey L Dupree, Venetia Zachariou, Jose C Clemente, Patrizia Casaccia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
microbiome
brain
psychiatry
myelin
behavior
gut
Online Access:https://elifesciences.org/articles/13442

Internet

https://elifesciences.org/articles/13442

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