Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions

Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions

Summary: The continual emergence of novel coronaviruses (CoV), such as severe acute respiratory syndrome-(SARS)-CoV-2, highlights the critical need for broadly reactive therapeutics and vaccines against this family of viruses. From a recovered SARS-CoV donor sample, we identify and characterize a pa...

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Bibliographic Details
Main Authors: Andrea R. Shiakolas, Kevin J. Kramer, Daniel Wrapp, Simone I. Richardson, Alexandra Schäfer, Steven Wall, Nianshuang Wang, Katarzyna Janowska, Kelsey A. Pilewski, Rohit Venkat, Robert Parks, Nelia P. Manamela, Nagarajan Raju, Emilee Friedman Fechter, Clinton M. Holt, Naveenchandra Suryadevara, Rita E. Chen, David R. Martinez, Rachel S. Nargi, Rachel E. Sutton, Julie E. Ledgerwood, Barney S. Graham, Michael S. Diamond, Barton F. Haynes, Priyamvada Acharya, Robert H. Carnahan, James E. Crowe, Jr., Ralph S. Baric, Lynn Morris, Jason S. McLellan, Ivelin S. Georgiev
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports Medicine
Subjects:
SARS-CoV-2
COVID-19
antibody discovery
cross-reactivity
Fc effector function
LIBRA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001567

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http://www.sciencedirect.com/science/article/pii/S2666379121001567

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