Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production

Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production

Primary Sjögren's syndrome (pSS) is a systemic auto-immune disease typified by dryness of the mouth and eyes. A majority of patients with pSS have a type-I interferon (IFN)-signature, which is defined as the increased expression of IFN-induced genes in circulating immune cells and is associated...

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Bibliographic Details
Main Authors: Maarten R. Hillen, Aridaman Pandit, Sofie L. M. Blokland, Sarita A. Y. Hartgring, Cornelis P. J. Bekker, Eefje H. M. van der Heijden, Nila H. Servaas, Marzia Rossato, Aike A. Kruize, Joel A. G. van Roon, Timothy R. D. J. Radstake
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Sjögren's syndrome
plasmacytoid dendritic cells
type-I interferon
transcriptomics
gene network analysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02096/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02096/full

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