Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma

Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma

Abstract Background Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a component of the Wnt receptor complex, is thought to lineage label gastric and intestinal stem cells. LGR5 expression is increased in colorectal carcinoma (CRC) compared to normal tissue. Colitis associated col...

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Bibliographic Details
Main Authors: Mai Iwaya, Hiroyoshi Ota, Tomoyuki Nakajima, Takeshi Uehara, Robert Riddell, James Conner
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
Inflammatory bowel disease
Ulcerative colitis
Crohn’s disease
Colitis associated colorectal carcinoma
LGR5
Online Access:https://doi.org/10.1186/s12885-021-07835-3

Internet

https://doi.org/10.1186/s12885-021-07835-3

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