Evaluation of T-Cell Responses Against Shared Melanoma Associated Antigens and Predicted Neoantigens in Cutaneous Melanoma Patients Treated With the CSF-470 Allogeneic Cell Vaccine Plus BCG and GM-CSF

Evaluation of T-Cell Responses Against Shared Melanoma Associated Antigens and Predicted Neoantigens in Cutaneous Melanoma Patients Treated With the CSF-470 Allogeneic Cell Vaccine Plus BCG and GM-CSF

The CSF-470 vaccine consists of lethally-irradiated allogeneic cells derived from four cutaneous melanoma cell lines administered plus BCG and GM-CSF as adjuvants. In an adjuvant phase II study vs. IFN-α2b, the vaccine significantly prolonged the distant metastasis-free survival (DMFS) of stages IIB...

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Bibliographic Details
Main Authors: Enrique Podaza, Ibel Carri, Mariana Aris, Erika von Euw, Alicia Inés Bravo, Paula Blanco, Juan Manuel Ortiz Wilczyñski, Daniel Koile, Patricio Yankilevich, Morten Nielsen, José Mordoh, María Marcela Barrio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
cutaneous melanoma
CSF-470 allogeneic cell vaccine
neoantigens
tumor associated antigens
melanoma immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01147/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01147/full

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