Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in the colon is not clear. Here, we show that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colo...

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Bibliographic Details
Main Authors: Karthikeyani Chellappa, Poonamjot Deol, Jane R Evans, Linh M Vuong, Gang Chen, Nadege Briançon, Eugene Bolotin, Christian Lytle, Meera G Nair, Frances M Sladek
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
nuclear receptor
alternative promoters
exon swap mice
colonic crypts
colitis
colon cancer
Online Access:https://elifesciences.org/articles/10903

Internet

https://elifesciences.org/articles/10903

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