Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by t...

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Bibliographic Details
Main Authors: Leonardo Dini, Martina Del Lungo, Francesco Resta, Michele Melchiorre, Valentina Spinelli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Annunziatina Laurino, Laura Sartiani, Raffaele Coppini, Guido Mannaioni, Elisabetta Cerbai, Maria Novella Romanelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
dorsal root ganglion neurons
hyperpolarization-activated current
HCN channel blockade
oxaliplatin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01252/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01252/full

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