Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway

Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by epithelial cell damage, myofibroblast activation, and collagen deposition. Multiple studies have documented that the Wnt/β-catenin pathway is aberrantly activated in IPF and plays a vital role in myofibroblast diffe...

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Bibliographic Details
Main Authors: Xiaohe Li, Xiaowei Liu, Ruxia Deng, Shaoyan Gao, Haiyan Yu, Kai Huang, Qiuyan Jiang, Rui Liu, Xiaoping Li, Liang Zhang, Honggang Zhou, Cheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
Nintedanib
Wnt/β-catenin
Src kinase
pulmonary fibrosis
myofibroblast
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00310/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00310/full

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