In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis, wound and nosocomial infections, posing a serious burden to public health, due to its antibiotic resistance. The P. aeruginosa Pseudomonas Quinolone System (pqs) quorum sensing system, driven by the activation of the transc...

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Bibliographic Details
Main Authors: Fadi Soukarieh, Eduard Vico Oton, Jean-Frédéric Dubern, Janice Gomes, Nigel Halliday, Maria de Pilar Crespo, Jonathan Ramírez-Prada, Braulio Insuasty, Rodrigo Abonia, Jairo Quiroga, Stephan Heeb, Paul Williams, Michael J. Stocks, Miguel Cámara
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
Pseudomonas aeruginosa
PqsR
MvfR
Pseudomonas quinolone signal (PQS)
alkylquinolone
quorum sensing inhibition.
Online Access:http://www.mdpi.com/1420-3049/23/2/257

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http://www.mdpi.com/1420-3049/23/2/257

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