Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling

Phenotypic switch of vascular smooth muscle cells (VSMCs) is important in vascular remodeling which causes hyperplasia and restenosis after intimal injury. Platelets are activated at injured intima and secrete platelet-derived microvesicles (PMVs). Herein, we demonstrated the role of PMVs in VSMC ph...

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Bibliographic Details
Main Authors: Ji-Ting Liu, Han Bao, Yang-Jing Fan, Zi-Tong Li, Qing-Ping Yao, Yue Han, Ming-Liang Zhang, Zong-Lai Jiang, Ying-Xin Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intimal hyperplasia
platelet-derived microvesicles
vascular smooth muscle cells
dedifferentiation
Lamtor1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.744320/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.744320/full

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