A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling.

A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling.

Kaposi's sarcoma (KS) is a highly disseminated angiogenic tumor of endothelial cells linked to infection by Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV encodes more than two dozens of miRNAs but their roles in KSHV-induced tumor dissemination and metastasis remain unknown. Here, w...

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Bibliographic Details
Main Authors: Minmin Hu, Cong Wang, Wan Li, Weiping Lu, Zhiqiang Bai, Di Qin, Qin Yan, Jianzhong Zhu, Brian J Krueger, Rolf Renne, Shou-Jiang Gao, Chun Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4581863?pdf=render

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http://europepmc.org/articles/PMC4581863?pdf=render

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