Germline mutation landscape of Chinese patients with familial breast/ovarian cancer in a panel of 22 susceptibility genes

Germline mutation landscape of Chinese patients with familial breast/ovarian cancer in a panel of 22 susceptibility genes

 Abstract Genetic testing for germline mutations in BRCA1/2 of patients with breast cancer (BC) is part of routine patient care. However, BRCA1/2 mutations account only for a fraction of familial BC. A custom panel of 22 gene sequencing was performed on each patient. Among the 481 female patients, 1...

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Bibliographic Details
Main Authors: Jiayu Wang, Weiwei Li, Yujian Shi, Yan Huang, Tao Sun, Lili Tang, Qing Lu, Qiumo Lei, Ning Liao, Feng Jin, Hui Li, Tao Huang, Jun Qian, Danmei Pang, Shusen Wang, Peizhi Fan, Xinhong Wu, Ying Lin, Haiyan Qin, Binghe Xu
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
BRCA1
BRCA2
familial breast cancer
multigenes
novel mutation
Online Access:https://doi.org/10.1002/cam4.2093

Internet

https://doi.org/10.1002/cam4.2093

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