Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

Sildenafil citrate undergoes first-pass metabolism, resulting in poor oral bioavailability at 25–41% of the administered dose. This study aimed to design and optimize fast-disintegrating tablets for the sublingual delivery of sildenafil citrate to improve bioavailability and facilitate rapid onset o...

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Bibliographic Details
Main Authors: Amer S. AlAli, Mohammed F. Aldawsari, Ahmed Alalaiwe, Bjad K. Almutairy, Ramadan Al-Shdefat, Ismail A. Walbi, Mohamed H. Fayed
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
sildenafil
sublingual tablets
quality by design
fluid-bed
oral bioavailability
Online Access:https://www.mdpi.com/1999-4923/13/6/870

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https://www.mdpi.com/1999-4923/13/6/870

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