Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Recent studies have shown that mutations in SQSTM1 are linked to ALS. SQSTM1 encodes SQSTM1/p62 that regulates not only autophagy via the associ...

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Bibliographic Details
Main Authors: Shun Mitsui, Asako Otomo, Masahisa Nozaki, Suzuka Ono, Kai Sato, Ryohei Shirakawa, Hiroaki Adachi, Masashi Aoki, Gen Sobue, Hui-Fang Shang, Shinji Hadano
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Brain
Subjects:
Amyotrophic lateral sclerosis
SOD1
SQSTM1/p62
Ubiquitin-positive aggregates
Online Access:http://link.springer.com/article/10.1186/s13041-018-0373-8

Internet

http://link.springer.com/article/10.1186/s13041-018-0373-8

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