Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

Abstract Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors. We previously reported that BTIC frequency ranges betwe...

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Bibliographic Details
Main Authors: William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar, John A. Hassell
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
Breast cancer
Breast tumorspheres
Breast tumor initiating cells
Serotonin receptor 5A antagonists
Phosphoproteomics
Online Access:http://link.springer.com/article/10.1186/s12885-020-07193-6

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http://link.springer.com/article/10.1186/s12885-020-07193-6

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