Imperatorin Interferes with LPS Binding to the TLR4 Co-Receptor and Activates the Nrf2 Antioxidative Pathway in RAW264.7 Murine Macrophage Cells

Imperatorin Interferes with LPS Binding to the TLR4 Co-Receptor and Activates the Nrf2 Antioxidative Pathway in RAW264.7 Murine Macrophage Cells

Imperatorin (IMP) could downregulate several inflammatory transcription factor signaling pathways. Some studies have pointed out that IMP could interfere with toll-like receptor 4 (TLR4) signaling. This study evaluates how IMP interferes with the TLR4 co-receptors signaling through the protein-ligan...

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Bibliographic Details
Main Authors: Mei-Hsuen Huang, Yu-Hsien Lin, Ping-Chiang Lyu, Yi-Chung Liu, Yuan-Shiun Chang, Jing-Gung Chung, Wei-Yong Lin, Wen-Tsong Hsieh
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antioxidants
Subjects:
imperatorin
Notopterygium incisum
anti-inflammatory effects
LPS/TLR4 signal transduction
Nrf2 antioxidative pathway
protein-ligand docking assay
Online Access:https://www.mdpi.com/2076-3921/10/3/362

Internet

https://www.mdpi.com/2076-3921/10/3/362

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