Influence of CYP3A5 and ABCB1 polymorphism on tacrolimus drug dosing in South Indian renal allograft recipients

Influence of CYP3A5 and ABCB1 polymorphism on tacrolimus drug dosing in South Indian renal allograft recipients

Introduction: Tacrolimus blood levels are influenced by polymorphisms involving Cytochrome 3A subfamily (CYP3A5) and P-Glycoprotein (ABCB-1) genes. However, their role in transplant outcomes was less studied in South Indian population. We studied the prevalence and impact of these polymorphisms in r...

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Bibliographic Details
Main Authors: M Edwin Fernando, Manokaran Sellappan, N D Srinivasa Prasad, Sujit Suren, K Thirumalvalavan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Indian Journal of Nephrology
Subjects:
Polymorphisms
rejection
renal transplant
tacrolimus
tacrolimus toxicity
Online Access:http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;issue=4;spage=261;epage=266;aulast=Fernando

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http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;issue=4;spage=261;epage=266;aulast=Fernando

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