Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation

Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation

Immune checkpoint inhibitors (ICIs) are revolutionizing cancer treatment. Nevertheless, their increasing use leads to an increase of immune-related adverse events (irAEs). Among them, ICI-associated myocarditis (ICIM) is a rare irAE with a high mortality rate. We aimed to characterize the transcript...

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Bibliographic Details
Main Authors: Daniel Finke, Markus B. Heckmann, Janek Salatzki, Johannes Riffel, Esther Herpel, Lucie M. Heinzerling, Benjamin Meder, Mirko Völkers, Oliver J. Müller, Norbert Frey, Hugo A. Katus, Florian Leuschner, Ziya Kaya, Lorenz H. Lehmann
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
PD1
PDL-1
CTLA4
CD8
virus myocarditis
ICI-associated myocarditis
Online Access:https://www.mdpi.com/2072-6694/13/10/2498

Internet

https://www.mdpi.com/2072-6694/13/10/2498

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