Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Abstract Background Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessive e-DNA production and its impact on asthma outcomes are limited. Obje...

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Bibliographic Details
Main Authors: Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz, Thomas Bahmer, Olaf Holz, Anne-Marie Kirsten, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz, Frauke Pedersen, the ALLIANCE study group
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Respiratory Research
Subjects:
Extracellular DNA
Neutrophil extracellular traps
Neutrophilic asthma
Asthma outcomes
Online Access:https://doi.org/10.1186/s12931-021-01759-z

Internet

https://doi.org/10.1186/s12931-021-01759-z

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