In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS.

In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS.

Mutations in the enzyme superoxide dismutase-1 (SOD1) cause hereditary variants of the fatal motor neuronal disease Amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous: neurotoxicity is derived not only from mutant motor neurons but also from mutant neighbourin...

Full description

Bibliographic Details
Main Authors: Payam Dibaj, Heinz Steffens, Jana Zschüntzsch, Fabien Nadrigny, Eike D Schomburg, Frank Kirchhoff, Clemens Neusch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3060882?pdf=render

Internet

http://europepmc.org/articles/PMC3060882?pdf=render

Similar Items