FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children

The dysfunction of FOXP3-positive regulatory T cells (Tregs) plays a key role in the pathogenesis of autoimmune diseases, including type 1 diabetes (T1D). However, previous studies analyzing the peripheral blood Treg compartment in patients with T1D have yielded partially conflicting results. Moreov...

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Bibliographic Details
Main Authors: Tyyne Viisanen, Ahmad M. Gazali, Emmi-Leena Ihantola, Ilse Ekman, Kirsti Näntö-Salonen, Riitta Veijola, Jorma Toppari, Mikael Knip, Jorma Ilonen, Tuure Kinnunen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
human
type 1 diabetes
immune regulation
T cells
regulatory T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00019/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00019/full

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