Reversal Effect of Oxypeucedanin on P-glycoprotein-mediated Drug Transport

Reversal Effect of Oxypeucedanin on P-glycoprotein-mediated Drug Transport

P-glycoprotein affects the transport of numerous drugs including chemotherapeutic drugs vincristine sulfate (VCR) and docetaxel (DTX), and is one of the main causes for multidrug resistance. Our previous studies have shown that oxypeucedanin (OPD) can enhance the intestinal transit of puerarin and V...

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Bibliographic Details
Main Authors: Wei Dong, Zhen-Gen Liao, Guo-Wei Zhao, Xue-Jing Guan, Jing Zhang, Xin-Li Liang, Ming Yang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
oxypeucedanin (OPD)
reversal effect
P-glycoprotein (P-gp)
transmembrane transport
Online Access:http://www.mdpi.com/1420-3049/23/8/1841

Internet

http://www.mdpi.com/1420-3049/23/8/1841

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