Regulation of sclerostin in glucocorticoid-induced osteoporosis (GIO) in mice and humans

Glucocorticoids (GC) are used for the treatment of inflammatory diseases, including various forms of arthritis. However, their use is limited, amongst others, by adverse effects on bone. The Wnt and bone formation inhibitor sclerostin was recently implicated in the pathogenesis of GC-induced osteopo...

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Bibliographic Details
Main Authors: Sylvia Thiele, Anke Hannemann, Maria Winzer, Ulrike Baschant, Heike Weidner, Matthias Nauck, Rajesh V Thakker, Martin Bornhäuser, Lorenz C Hofbauer, Martina Rauner
Format: Article
Language:English
Published: Bioscientifica 2019-07-01
Series:Endocrine Connections
Subjects:
Online Access:https://ec.bioscientifica.com/view/journals/ec/8/7/EC-19-0104.xml