C-terminal region of EBNA-2 determines the superior transforming ability of type 1 Epstein-Barr virus by enhanced gene regulation of LMP-1 and CXCR7.

C-terminal region of EBNA-2 determines the superior transforming ability of type 1 Epstein-Barr virus by enhanced gene regulation of LMP-1 and CXCR7.

Type 1 Epstein-Barr virus (EBV) strains immortalize B lymphocytes in vitro much more efficiently than type 2 EBV, a difference previously mapped to the EBNA-2 locus. Here we demonstrate that the greater transforming activity of type 1 EBV correlates with a stronger and more rapid induction of the vi...

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Bibliographic Details
Main Authors: Laila Cancian, Rachel Bosshard, Walter Lucchesi, Claudio Elgueta Karstegl, Paul J Farrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3145799?pdf=render

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http://europepmc.org/articles/PMC3145799?pdf=render

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