APC and chromosome instability in colorectal cancer

APC and chromosome instability in colorectal cancer

Colon cancer is a common disease that can be sporadic or familial. An inactivated adenomatous polyposis coli (APC) suppressor gene is found in over 80% of colorectal tumors, this being an early alteration in the development of adenomatous polyps. APC function is not only critical for tumor initiatio...

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Bibliographic Details
Main Authors: C. M. Cabrera, M. A. López-Nevot
Format: Article
Language:English
Published: Aran Ediciones
Series:Revista Espanola de Enfermedades Digestivas
Subjects:
Cáncer de colon
APC
Inestabilidad cromosómica
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082005001000006&lng=en&tlng=en
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spelling doaj-85a158fd712d4918a91731433f6ae9572020-11-24T22:02:29ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01089710738743S1130-01082005001000006APC and chromosome instability in colorectal cancerC. M. Cabrera0M. A. López-Nevot1Hospital Universitario Virgen de las NievesHospital Universitario Virgen de las NievesColon cancer is a common disease that can be sporadic or familial. An inactivated adenomatous polyposis coli (APC) suppressor gene is found in over 80% of colorectal tumors, this being an early alteration in the development of adenomatous polyps. APC function is not only critical for tumor initiation and progression, and chromosome instability (CIN) is another characteristic dependent at least partly on APC mutations.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082005001000006&lng=en&tlng=enCáncer de colonAPCInestabilidad cromosómica
collection DOAJ
language English
format Article
sources DOAJ
author C. M. Cabrera
M. A. López-Nevot
spellingShingle C. M. Cabrera
M. A. López-Nevot
APC and chromosome instability in colorectal cancer
Revista Espanola de Enfermedades Digestivas
Cáncer de colon
APC
Inestabilidad cromosómica
author_facet C. M. Cabrera
M. A. López-Nevot
author_sort C. M. Cabrera
title APC and chromosome instability in colorectal cancer
title_short APC and chromosome instability in colorectal cancer
title_full APC and chromosome instability in colorectal cancer
title_fullStr APC and chromosome instability in colorectal cancer
title_full_unstemmed APC and chromosome instability in colorectal cancer
title_sort apc and chromosome instability in colorectal cancer
publisher Aran Ediciones
series Revista Espanola de Enfermedades Digestivas
issn 1130-0108
description Colon cancer is a common disease that can be sporadic or familial. An inactivated adenomatous polyposis coli (APC) suppressor gene is found in over 80% of colorectal tumors, this being an early alteration in the development of adenomatous polyps. APC function is not only critical for tumor initiation and progression, and chromosome instability (CIN) is another characteristic dependent at least partly on APC mutations.
topic Cáncer de colon
APC
Inestabilidad cromosómica
url http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082005001000006&lng=en&tlng=en
work_keys_str_mv AT cmcabrera apcandchromosomeinstabilityincolorectalcancer
AT malopeznevot apcandchromosomeinstabilityincolorectalcancer
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