Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus

<p>Abstract</p> <p>Background</p> <p>The interpandemic evolution of the influenza A virus hemagglutinin (HA) protein is commonly considered a paragon of rapid evolutionary change under positive selection in which amino acid replacements are fixed by virtue of their effe...

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Bibliographic Details
Main Authors: Koonin Eugene V, Holmes Edward C, Viboud Cecile, Wolf Yuri I, Lipman David J
Format: Article
Language:English
Published: BMC 2006-10-01
Series:Biology Direct
Online Access:http://www.biology-direct.com/content/1/1/34