Voltage-gated sodium channels assemble and gate as dimers

Voltage-gated sodium channels assemble and gate as dimers

Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.

Bibliographic Details
Main Authors: Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02262-0
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spelling doaj-85a3e4c0115748e58575917074c2df762021-05-11T07:07:40ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02262-0Voltage-gated sodium channels assemble and gate as dimersJérôme Clatot0Malcolm Hoshi1Xiaoping Wan2Haiyan Liu3Ankur Jain4Krekwit Shinlapawittayatorn5Céline Marionneau6Eckhard Ficker7Taekjip Ha8Isabelle Deschênes9Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityHeart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityHeart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityHeart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityDepartment of Physics, University of Illinois at Urbana-ChampaignHeart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityL’Institut du Thorax, INSERM, CNRS, UNIV NantesHeart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityDepartment of Physics, University of Illinois at Urbana-ChampaignHeart and Vascular Research Center, MetroHealth Campus, Case Western Reserve UniversityVoltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.https://doi.org/10.1038/s41467-017-02262-0
collection DOAJ
language English
format Article
sources DOAJ
author Jérôme Clatot
Malcolm Hoshi
Xiaoping Wan
Haiyan Liu
Ankur Jain
Krekwit Shinlapawittayatorn
Céline Marionneau
Eckhard Ficker
Taekjip Ha
Isabelle Deschênes
spellingShingle Jérôme Clatot
Malcolm Hoshi
Xiaoping Wan
Haiyan Liu
Ankur Jain
Krekwit Shinlapawittayatorn
Céline Marionneau
Eckhard Ficker
Taekjip Ha
Isabelle Deschênes
Voltage-gated sodium channels assemble and gate as dimers
Nature Communications
author_facet Jérôme Clatot
Malcolm Hoshi
Xiaoping Wan
Haiyan Liu
Ankur Jain
Krekwit Shinlapawittayatorn
Céline Marionneau
Eckhard Ficker
Taekjip Ha
Isabelle Deschênes
author_sort Jérôme Clatot
title Voltage-gated sodium channels assemble and gate as dimers
title_short Voltage-gated sodium channels assemble and gate as dimers
title_full Voltage-gated sodium channels assemble and gate as dimers
title_fullStr Voltage-gated sodium channels assemble and gate as dimers
title_full_unstemmed Voltage-gated sodium channels assemble and gate as dimers
title_sort voltage-gated sodium channels assemble and gate as dimers
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.
url https://doi.org/10.1038/s41467-017-02262-0
work_keys_str_mv AT jeromeclatot voltagegatedsodiumchannelsassembleandgateasdimers
AT malcolmhoshi voltagegatedsodiumchannelsassembleandgateasdimers
AT xiaopingwan voltagegatedsodiumchannelsassembleandgateasdimers
AT haiyanliu voltagegatedsodiumchannelsassembleandgateasdimers
AT ankurjain voltagegatedsodiumchannelsassembleandgateasdimers
AT krekwitshinlapawittayatorn voltagegatedsodiumchannelsassembleandgateasdimers
AT celinemarionneau voltagegatedsodiumchannelsassembleandgateasdimers
AT eckhardficker voltagegatedsodiumchannelsassembleandgateasdimers
AT taekjipha voltagegatedsodiumchannelsassembleandgateasdimers
AT isabelledeschenes voltagegatedsodiumchannelsassembleandgateasdimers
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