Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.

by Drew M Nassal, Xiaoping Wan, Haiyan Liu, Isabelle Deschênes
Published 2016-01-01

Long QT syndrome – Bench to bedside

by Daniela Ponce-Balbuena, PhD, Isabelle Deschênes, PhD
Published 2021-02-01

KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity.

by Drew M Nassal, Xiaoping Wan, Haiyan Liu, Kenneth R Laurita, Isabelle Deschênes
Published 2017-01-01

Polygenic case of long QT syndrome confirmed through functional characterization informs the interpretation of genetic screening results

by Malcolm Hoshi, BA, Haiyan Liu, MD, Elizabeth S. Kaufman, MD, FHRS, Isabelle Deschênes, PhD
Published 2015-07-01

Inhibition of CREB-CBP Signaling Improves Fibroblast Plasticity for Direct Cardiac Reprogramming

by Emre Bektik, Yu Sun, Adrienne T. Dennis, Phraew Sakon, Dandan Yang, Isabelle Deschênes, Ji-Dong Fu
Published 2021-06-01

iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

by Hugo Poulin, Aurélie Mercier, Mohammed Djemai, Valérie Pouliot, Isabelle Deschenes, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine
Published 2021-01-01

A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

by Yang Zheng, Yang Zheng, Xiaoping Wan, Dandan Yang, Angelina Ramirez-Navarro, Haiyan Liu, Ji-Dong Fu, Isabelle Deschênes
Published 2021-03-01

Voltage-gated sodium channels assemble and gate as dimers

by Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes
Published 2017-12-01

S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit

by Emre Bektik, Adrienne Dennis, Gary Pawlowski, Chen Zhou, Danielle Maleski, Satoru Takahashi, Kenneth R. Laurita, Isabelle Deschênes, Ji-Dong Fu
Published 2018-05-01

KChIP2 is a core transcriptional regulator of cardiac excitability

by Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes
Published 2017-03-01

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

by Rengasayee Veeraraghavan, Gregory S Hoeker, Anita Alvarez-Laviada, Daniel Hoagland, Xiaoping Wan, D Ryan King, Jose Sanchez-Alonso, Chunling Chen, Jane Jourdan, Lori L Isom, Isabelle Deschenes, James W Smyth, Julia Gorelik, Steven Poelzing, Robert G Gourdie
Published 2018-08-01

Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

by Alain Meyer, Yves Troyanov, Julie Drouin, Geneviève Oligny-Longpré, Océane Landon-Cardinal, Sabrina Hoa, Baptiste Hervier, Josiane Bourré-Tessier, Anne-Marie Mansour, Sara Hussein, Vincent Morin, Eric Rich, Jean-Richard Goulet, Sandra Chartrand, Marie Hudson, Jessica Nehme, Jean-Paul Makhzoum, Farah Zarka, Edith Villeneuve, Jean-Pierre Raynauld, Marianne Landry, Erin K. O’Ferrall, Jose Ferreira, Benjamin Ellezam, Jason Karamchandani, Sandrine Larue, Rami Massie, Catherine Isabelle, Isabelle Deschênes, Valérie Leclair, Hélène Couture, Ira N. Targoff, Marvin J. Fritzler, Jean-Luc Senécal
Published 2020-01-01