A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Nav1.5 Gating Pores

by Adrien Moreau, Mohamed Chahine, Mohamed Chahine
Published 2018-10-01

NaV1.5 knockout in iPSCs: a novel approach to study NaV1.5 variants in a human cardiomyocyte environment

by Marion Pierre, Mohammed Djemai, Hugo Poulin, Mohamed Chahine
Published 2021-08-01

iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

by Hugo Poulin, Aurélie Mercier, Mohammed Djemai, Valérie Pouliot, Isabelle Deschenes, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine
Published 2021-01-01

Correction: A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype

by Pascal Gosselin-Badaroudine, Dagmar I. Keller, Hai Huang, Valérie Pouliot, Aurélien Chatelier, Stefan Osswald, Marijke Brink, Mohamed Chahine
Published 2012-01-01

A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype.

by Pascal Gosselin-Badaroudine, Dagmar I Keller, Hai Huang, Valérie Pouliot, Aurélien Chatelier, Stefan Osswald, Marijke Brink, Mohamed Chahine
Published 2012-01-01

Correction: A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype.

by Pascal Gosselin-Badaroudine, Dagmar I. Keller, Hai Huang, Valérie Pouliot, Aurélien Chatelier, Stefan Osswald, Marijke Brink, Mohamed Chahine
Published 2012-01-01

The β1-subunit of Na(v)1.5 cardiac sodium channel is required for a dominant negative effect through α-α interaction.

by Aurélie Mercier, Romain Clément, Thomas Harnois, Nicolas Bourmeyster, Jean-François Faivre, Ian Findlay, Mohamed Chahine, Patrick Bois, Aurélien Chatelier
Published 2012-01-01

Pyrethroids differentially alter voltage-gated sodium channels from the honeybee central olfactory neurons.

by Aklesso Kadala, Mercedes Charreton, Ingrid Jakob, Thierry Cens, Matthieu Rousset, Mohamed Chahine, Yves Le Conte, Pierre Charnet, Claude Collet
Published 2014-01-01

Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

by Ademuyiwa S Aromolaran, Ujala Srivastava, Alessandra Alí, Mohamed Chahine, Deana Lazaro, Nabil El-Sherif, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Pietro Enea Lazzerini, Mohamed Boutjdir
Published 2018-01-01

A Novel and Simple Exercise Test Parameter to Assess Responsiveness to Cardiac Resynchronization Therapy

by Alina-Ramona Cozlac, Lucian Petrescu, Simina Crisan, Constantin Tudor Luca, Cristina Vacarescu, Caius Glad Streian, Mihai-Andrei Lazar, Andra Gurgu, Angela Dragomir, Emilia Violeta Goanta, Radu Vatasescu, Kandara Mohamed Chahine, Ciprian Rachieru, Dragos Cozma
Published 2020-11-01

Novel G1481V and Q1491H SCN5A Mutations Linked to Long QT Syndrome Destabilize the Nav1.5 Inactivation State

by Quentin Plumereau, MSc, Olivier Theriault, PhD, Valérie Pouliot, BSc, Adrien Moreau, PhD, Elodie Morel, PhD, Véronique Fressart, MD, PhD, Isabelle Denjoy, MD, Antoine Delinière, MD, Francis Bessière, MD, Philippe Chevalier, MD, Tamer M. Gamal El-Din, PhD, Mohamed Chahine, PhD
Published 2021-03-01

Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia

by Weilai Dong, Sheng Chih Jin, August Allocco, Xue Zeng, Amar H. Sheth, Shreyas Panchagnula, Annie Castonguay, Louis-Étienne Lorenzo, Barira Islam, Geneviève Brindle, Karine Bachand, Jamie Hu, Agata Sularz, Jonathan Gaillard, Jungmin Choi, Ashley Dunbar, Carol Nelson-Williams, Emre Kiziltug, Charuta Gavankar Furey, Sierra Conine, Phan Q. Duy, Adam J. Kundishora, Erin Loring, Boyang Li, Qiongshi Lu, Geyu Zhou, Wei Liu, Xinyue Li, Michael C. Sierant, Shrikant Mane, Christopher Castaldi, Francesc López-Giráldez, James R. Knight, Raymond F. Sekula, Jr., J. Marc Simard, Emad N. Eskandar, Christopher Gottschalk, Jennifer Moliterno, Murat Günel, Jason L. Gerrard, Sulayman Dib-Hajj, Stephen G. Waxman, Fred G. Barker, II, Seth L. Alper, Mohamed Chahine, Shozeb Haider, Yves De Koninck, Richard P. Lifton, Kristopher T. Kahle
Published 2020-10-01