Multi-Omics Integration Highlights the Role of Ubiquitination in CCl<sub>4</sub>-Induced Liver Fibrosis

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl<sub>4</sub>-Induced Liver Fibrosis

Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological processes. Even though the ubiquitin system has been implicated in several human dis...

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Bibliographic Details
Main Authors: Maria Mercado-Gómez, Fernando Lopitz-Otsoa, Mikel Azkargorta, Marina Serrano-Maciá, Sofia Lachiondo-Ortega, Naroa Goikoetxea-Usandizaga, Rubén Rodríguez-Agudo, David Fernández-Ramos, Maider Bizkarguenaga, Virginia Gutiérrez-de Juan, Benoît Lectez, Kerman Aloria, Jesus M. Arizmendi, Jorge Simon, Cristina Alonso, Juan J. Lozano, Matias A. Avila, Jesus M. Banales, Jose J. G. Marin, Naiara Beraza, José M. Mato, Félix Elortza, Rosa Barrio, James D. Sutherland, Ugo Mayor, María L. Martínez-Chantar, Teresa C. Delgado
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
liver fibrosis
ubiquitination
metabolomics
proliferating cell nuclear antigen (PCNA)
DNA damage response (DDR)
Online Access:https://www.mdpi.com/1422-0067/21/23/9043

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https://www.mdpi.com/1422-0067/21/23/9043

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