The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

The Sec61-complex as a dynamic polypeptide-conducting channel mediates protein transport into the human endoplasmic reticulum (ER) with the help of additional components. ER membrane resident Hsp40-type co-chaperone Sec63 as well as the ER lumenal Hsp70-type chaperone BiP were proposed to facilitate...

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Bibliographic Details
Main Authors: Anke Ziska, Jörg Tatzelt, Johanna Dudek, Adrienne W. Paton, James C. Paton, Richard Zimmermann, Sarah Haßdenteufel
Format: Article
Language:English
Published: The Company of Biologists 2019-03-01
Series:Biology Open
Subjects:
Protein targeting and translocation
BiP
Sec63
Cluster of positive charges
Mature region
Signal peptide
Online Access:http://bio.biologists.org/content/8/3/bio040691

Internet

http://bio.biologists.org/content/8/3/bio040691

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