The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating
The Sec61-complex as a dynamic polypeptide-conducting channel mediates protein transport into the human endoplasmic reticulum (ER) with the help of additional components. ER membrane resident Hsp40-type co-chaperone Sec63 as well as the ER lumenal Hsp70-type chaperone BiP were proposed to facilitate...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2019-03-01
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Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/8/3/bio040691 |