The Molecular Landscape and Biological Alterations Induced by PRAS40-Knockout in Head and Neck Squamous Cell Carcinoma

The Molecular Landscape and Biological Alterations Induced by PRAS40-Knockout in Head and Neck Squamous Cell Carcinoma

PRAS40 (Prolin-rich Akt substrate of 40 kDa) is a critical protein, which directly connects PI3K/Akt and mTORC1 pathway. It plays an indispensable role in the development of various diseases. However, the relationship between PRAS40 and head and neck squamous cell carcinoma (HNSCC) remains unclear....

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Bibliographic Details
Main Authors: Gang Chen, Zhexuan Li, Changhan Chen, Jiajia Liu, Weiming Zhu, Li She, Huimei Huang, Yuexiang Qin, Guancheng Liu, Juncheng Wang, Yong Liu, Donghai Huang, Qinglai Tang, Xin Zhang, Gangcai Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
head and neck squamous cell carcinoma
prolin-rich Akt substrate of 40 kDa
CRISPR/Cas9
metastasis
The Cancer Genome Atlas
immunomicro-environment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.565669/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.565669/full

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