N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway

N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway

Abstract Background Cerebral arteriovenous malformation (AVM) is a serious life-threatening congenital cerebrovascular disease. Specific anatomical features, such as nidus size, location, and venous drainage, have been validated to affect treatment outcomes. Until recently, molecular biomarkers and...

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Bibliographic Details
Main Authors: Lin-jian Wang, Yimeng Xue, Ran Huo, Zihan Yan, Hongyuan Xu, Hao Li, Jia Wang, Qian Zhang, Yong Cao, Ji-zong Zhao
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Biomedical Science
Subjects:
Cerebral arteriovenous malformation
METTL3
Nidus size
Notch signaling pathway
DTX3L
Angiogenesis
Online Access:http://link.springer.com/article/10.1186/s12929-020-00655-w

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http://link.springer.com/article/10.1186/s12929-020-00655-w

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