Small peptide-based GLP-1R ligands: an approach to reduce the kidney uptake of radiolabeled GLP-1R-targeting agents?

Small peptide-based GLP-1R ligands: an approach to reduce the kidney uptake of radiolabeled GLP-1R-targeting agents?

Abstract Aim Elevated kidney uptake in insulinoma patients remains a major limitation of radiometallated exendin-derived ligands of the glucagon-like peptide 1 receptor (GLP-1R). Based on the previously published potent GLP-1R-activating undecapeptide 1, short-chained GLP-1R ligands were developed t...

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Bibliographic Details
Main Authors: Veronika Barbara Felber, Hans-Jürgen Wester
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
GLP-1R
Small peptides
Insulinoma
Diagnosis
Peptide receptor radionuclide therapy
Kidneys
Online Access:https://doi.org/10.1186/s41181-021-00136-x

Internet

https://doi.org/10.1186/s41181-021-00136-x

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