Neprilysin and Aβ-clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer´s disease

Neprilysin and Aβ-clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer´s disease

Abstract: One of the characteristic hallmarks of Alzheimer´s disease (AD) is an accumulation of Amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the de novo synthesis of Aβ caused by amyloidogenic processing of the Amyloid precursor protein (APP), Aβ lev...

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Bibliographic Details
Main Authors: Marcus O Grimm, Janine eMett, Christoph Peter Stahlmann, Viola Jessica Haupenthal, Valerie Christin Zimmer, Tobias eHartmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
Neprilysin
Transcriptional regulation
Alzheimer´s disease
Amyloid beta
AICD
Abeta degradation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00098/full

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