Requirements for a Robust Animal Model to Investigate the Disease Mechanism of Autoimmune Complications Associated With ARF/RHD

Requirements for a Robust Animal Model to Investigate the Disease Mechanism of Autoimmune Complications Associated With ARF/RHD

The pathogenesis of Acute Rheumatic Fever/Rheumatic Heart Disease (ARF/RHD) and associated neurobehavioral complications including Sydenham's chorea (SC) is complex. Disease complications triggered by Group A streptococcal (GAS) infection are confined to human and determining the early events l...

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Bibliographic Details
Main Authors: Rukshan A. M. Rafeek, Suchandan Sikder, Adam S. Hamlin, Nicholas M. Andronicos, David J. McMillan, Kadaba S. Sriprakash, Natkunam Ketheesan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
animal model
acute rheumatic fever
rheumatic heart disease
sydenham chorea
lewis rats
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.675339/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.675339/full

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