Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells

Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells

Fibroblastic reticular cells (FRCs) are the specialized lymphoid stromal cells initially identified as triggering T-cell recruitment and dynamic motion in secondary lymphoid organs. Interestingly, FRCs also display antigen presentation capacities and support lymphocyte survival. CXCR5+CD4+ follicula...

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Bibliographic Details
Main Authors: Jan Misiak, Rachel Jean, Stéphane Rodriguez, Laurent Deleurme, Thierry Lamy, Karin Tarte, Patricia Amé-Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
IL-4
fibroblastic reticular cells
follicular T cells
T follicular helper cells
follicular lymphoma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.559866/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.559866/full

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