SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition

SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition

Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection despite abundant expression of antiviral proteins. Perhaps the most important antiviral protein is the restriction factor sterile alpha motif domain and histidine/aspartic acid domain-containing protein 1 (SAMHD1)....

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Bibliographic Details
Main Authors: Matthew A. Szaniawski, Adam M. Spivak, James E. Cox, Jonathan L. Catrow, Timothy Hanley, Elizabeth S. C. P. Williams, Michel J. Tremblay, Alberto Bosque, Vicente Planelles
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
CDK1
dasatinib
interferon
human immunodeficiency virus
macrophages
Online Access:https://doi.org/10.1128/mBio.00819-18

Internet

https://doi.org/10.1128/mBio.00819-18

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