A stereo, regioselective synthesis and discovery of antimycobaterium tuberculosis activity of novel β-lactam grafted spirooxindolopyrrolidine hybrid heterocycles

A stereo, regioselective synthesis and discovery of antimycobaterium tuberculosis activity of novel β-lactam grafted spirooxindolopyrrolidine hybrid heterocycles

A stereo- and regioselective synthesis of hitherto unexplored novel class of β-lactam embedded spirooxindolopyrrolidine hybrid heterocycles have been accomplished via ionic liquid accelerated [3 + 2]-cycloaddition reaction process. The expected unusual lactonization/lactamization product could not b...

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Bibliographic Details
Main Authors: Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Vagolu Siva Krishna, Dharmarajan Sriram, Ramanathan Padmanaban
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Arabian Journal of Chemistry
Subjects:
Spirooxindolopyrrolidines
β-lactam
1,3-Dipolar cycloaddition reaction
Ionic liquids
DFT study
Mycobacterium tuberculosis activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220304998

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http://www.sciencedirect.com/science/article/pii/S1878535220304998

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