Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial toxicity and more specific therapies targeting the underlying molecular lesions are highly desired. Perturbed Ras signaling is prevalent in T-ALL a...

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Bibliographic Details
Main Authors: Olga Ksionda, Marsilius Mues, Anica M Wandler, Lisa Donker, Milou Tenhagen, Jesse Jun, Gregory S Ducker, Ksenia Matlawska-Wasowska, Kevin Shannon, Kevan M Shokat, Jeroen P Roose
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5969748?pdf=render

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http://europepmc.org/articles/PMC5969748?pdf=render

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