Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Injectable therapeutic formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest in the scientific community, with the aim to overcome the cons of traditional administration routes. In this work, we proposed an alternative...

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Bibliographic Details
Main Authors: Monica Boffito, Alessandro Torchio, Chiara Tonda-Turo, Rossella Laurano, Miguel Gisbert-Garzarán, Julia C. Berkmann, Claudio Cassino, Miguel Manzano, Georg N. Duda, María Vallet-Regí, Katharina Schmidt-Bleek, Gianluca Ciardelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
thermo-sensitive hydrogels
polyurethane
pH-sensitive mesoporous silica nanoparticles
self-immolative polymer
triggered drug release
stimuli-responsive
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00384/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00384/full

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