EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells.

EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells.

Epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have been widely used in patients with non-small-cell lung cancer. Unfortunately, the efficacy of EGFR-TKIs is limited because of natural and acquired resistance. As a novel cytoprotective mechanism for tumor cell to...

Full description

Bibliographic Details
Main Authors: Weidong Han, Hongming Pan, Yan Chen, Jie Sun, Yanshan Wang, Jing Li, Weiting Ge, Lifeng Feng, Xiaoying Lin, Xiaojia Wang, Xian Wang, Hongchuan Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3107207?pdf=render

Internet

http://europepmc.org/articles/PMC3107207?pdf=render

Similar Items