Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

<b>Background</b>: New treatments are needed to reduce myocardial infarct size (MI) and prevent heart failure (HF) following acute myocardial infarction (AMI), which are the leading causes of death and disability worldwide. Studies in rodent AMI models showed that genetic and pharmacolog...

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Bibliographic Details
Main Authors: Sang-Bing Ong, Xiu-Yi Kwek, Khairunnisa Katwadi, Sauri Hernandez-Resendiz, Gustavo E. Crespo-Avilan, Nur Izzah Ismail, Ying-Hsi Lin, En Ping Yap, Song-Yi Lim, K P Myu Mai Ja, Chrishan J.A. Ramachandra, Nicole Tee, Jin Jiat Toh, Winston Shim, Philip Wong, Hector A. Cabrera-Fuentes, Derek J Hausenloy
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
mdivi-1
mitochondrial morphology
cardioprotection
Drp1
pig
ischemia/reperfusion injury
Online Access:https://www.mdpi.com/1422-0067/20/16/3972

Internet

https://www.mdpi.com/1422-0067/20/16/3972

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