Ketone Body 3‐Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a‐Mediated Calcium Influx

Ketone Body 3‐Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a‐Mediated Calcium Influx

Abstract Atherosclerosis is a chronic inflammatory disease that can cause acute cardiovascular events. Activation of the NOD‐like receptor family, pyrin domain containing protein 3 (NLRP3) inflammasome enhances atherogenesis, which links lipid metabolism to sterile inflammation. This study examines...

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Bibliographic Details
Main Authors: Shu‐jie Zhang, Zi‐hua Li, Yu‐dian Zhang, Jin Chen, Yuan Li, Fu‐qing Wu, Wei Wang, Zong Jie Cui, Guo‐Qiang Chen
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Advanced Science
Subjects:
3‐HB
atherosclerosis
calcium influx
cholesterol efflux
M1 macrophages
NLRP3
Online Access:https://doi.org/10.1002/advs.202003410

Internet

https://doi.org/10.1002/advs.202003410

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