Stem cell‐derived retinal pigment epithelium from patients with age‐related macular degeneration exhibit reduced metabolism and matrix interactions

Stem cell‐derived retinal pigment epithelium from patients with age‐related macular degeneration exhibit reduced metabolism and matrix interactions

Abstract Modeling age‐related macular degeneration (AMD) is challenging, because it is a multifactorial disease. To focus on interactions between the retinal pigment epithelium (RPE) and Bruch's membrane, we generated RPE from AMD patients and used an altered extracellular matrix (ECM) that mod...

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Bibliographic Details
Main Authors: Jie Gong, Hui Cai, NYSCF Global Stem Cell Array Team, Scott Noggle, Daniel Paull, Lawrence J. Rizzolo, Lucian V. Del Priore, Mark A. Fields
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Stem Cells Translational Medicine
Subjects:
age‐related macular degeneration
aging
Bruch's membrane
induced pluripotent stem cells
nonenzymatic nitration
retinal pigment epithelium
Online Access:https://doi.org/10.1002/sctm.19-0321

Internet

https://doi.org/10.1002/sctm.19-0321

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