TLR7 is expressed by support cells, but not sensory neurons, in ganglia

TLR7 is expressed by support cells, but not sensory neurons, in ganglia

Abstract Background Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7 agonists also modulate sensory nerve function by increasing neuronal excitability,...

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Bibliographic Details
Main Authors: Becky J. Proskocil, Karol Wai, Katherine M. Lebold, Mason A. Norgard, Katherine A. Michaelis, Ubaldo De La Torre, Madeline Cook, Daniel L. Marks, Allison D. Fryer, David B. Jacoby, Matthew G. Drake
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Dorsal root ganglia
Iba1 (ionized calcium-binding adaptor molecule 1)
GFAP (glial fibrillary acidic protein)
Influenza A
Sensory nerve
TLR7 (Toll-like receptor 7)
Online Access:https://doi.org/10.1186/s12974-021-02269-x

Internet

https://doi.org/10.1186/s12974-021-02269-x

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